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| Product Name | CUL2, GST-Tag, Recombinant (MGC131970, Cullin-2) |
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| Description | Lysate. Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). Source: Partial length protein corresponding to of CUL2, fused to GST-Tag at N-terminal, expressed in E. coli. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Molecular Weight: ~47kD |
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| Size | 200ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | CUL2, Gene ID: 8453, Accession: NP_003582, SwissProt: Q13617 |
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| Catalog # | 500686 |
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| Order / More Info | CUL2, GST-Tag, Recombinant (MGC131970, Cullin-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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