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| Product Name | Iduronidase, a-L-, Recombinant, Human, aa26-653, His-Tag (a-L-Iduronidase, IDUA) |
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| Description | Purity ~ 95%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: ≤ 1EU/ug (LAL). Alpha-L-Iduronidase encoded by the IDUA gene is an important enzyme required for the lysosomal degradation of glycosaminoglycans (GAGs). It hydrolyzes the non-reducing terminal alpha-L-iduronic acid residues in GAGs including dermatan sulfate and heparan sulfate. Mutations in IDUA that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I) (1). MPS I causes progressive cellular, tissue and organ damage, and several clinical studies using enzyme replacement therapy have shown promising benefits (2). The purified rhIDUA has an N-terminal sequence of T26EAPHLVQVD. The 638 amino acid residue rhIDUA predicts a molecular mass of 71kD, and migrates as an ~83 kD protein by SDS-PAGE under reducing conditions. Recombinant protein corresponding to Ala26-Pro653 (Ala26Thr) with a C-terminal 10-His tag expressed in NSO cells (AAA81589). Molecular Mas |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 3425, Accession: AAA81589 |
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| Catalog # | I0706-94 |
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| Order / More Info | Iduronidase, a-L-, Recombinant, Human, aa26-653, His-Tag (a-L-Iduronidase, IDUA) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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