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| Product Name | PCAF, active (p300/CBP-associated factor, CREBBP-associated factor, CAF, P/CAF) |
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| Description | Purity ~30%. A direct link exists between hyperacetylation of chromatin and transcriptional activation. Experiments have established that PCAF possesses intrinsic histone acetylase activity. PCAF primarily acetylates lysine 14 of H3. It acetylates lysine 8 of H4 less efficiently. PCAF also acetylates p53 in response to DNA damage. The distinct patterns of acetylation by PCAF may contribute to transcriptional regulation of important genes. Source: Expressed in E. coli corresponding to aa352-832. Quality Control: HAT Assay: 500ng of PCAF was used to acetylate histones in vitro with tracer levels of [3H]AcetylCoA as the acetyl donor. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q92831 |
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| Catalog # | P3114 |
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| Order / More Info | PCAF, active (p300/CBP-associated factor, CREBBP-associated factor, CAF, P/CAF) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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