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| Product Name | pCAF Inhibitor Screening BioAssay™ Kit (Fluorometric) |
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| Description | pCAF (P300/CBP-associated factor, EC 2.3.1.48) also known as K (lysine) acetyltransferase 2B (KAT2B), possesses intrinsic histone acetyltransferase (HAT) activity. pCAF contributes to transcriptional activation by acetylating chromatin and transcription factors through its HAT activity. Deregulated HAT activity plays an important role in various cancers. pCAF inhibitors have potential applications in cancer therapy. pCAF uses both histone 3 (H3) and histone 4 (H4) as substrates. Intended Use: For screening, studying and characterizing potential inhibitors of pCAF. Test Principle: The pCAF Inhibitor Screening BioAssay™ Kit utilizes H3 peptide and Acetyl CoA as the substrates. pCAF acetylates the peptide and generates Coenzyme A with a free thiol group. The CoA is detected using a Thiol Detecting Probe that reacts with thiol groups and gives enhanced fluorescence that can be measured at Ex/Em = 392/482nm. In the presence of pCAF specific inhibitors, the enzymatic activity is inhibi |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 220132 |
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| Order / More Info | pCAF Inhibitor Screening BioAssay™ Kit (Fluorometric) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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