| 产品详情 |
| Edit |   |
|---|
| Product Name | PCAF, Recombinant, Human, aa714-831, GST-tag (p300/CBP-Associated Factor, KAT2B) |
|---|
| Description | Purity ~95% (SDS-PAGE). The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as ``readers'' of histone acetylation marks regulating the transcription of target promoters. p300/CBP-associated factor (PCAF) is a transcriptional coactivator that works both as a histone lysine acetyltransferase, through its HAT domain, and as an acetyl-lysine reader through its conserved bromodomain located directly C-terminal to the HAT domain. The PCAF bromodomain binds acetylated histone H3 and H4 as well as non-histone targets. Bromodomain binding is |
|---|
| Size | 20ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | p300/CBP-associated factor; KAT2B |
|---|
| Gene, Accession, CAS # | KAT2B, Gene ID: 8850, SwissProt: Q92831 |
|---|
| Catalog # | 220135 |
|---|
| Price | |
|---|
| Order / More Info | PCAF, Recombinant, Human, aa714-831, GST-tag (p300/CBP-Associated Factor, KAT2B) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|