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| Product Name | PCAF, Recombinant, Mouse, His-tag |
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| Description | Purity ~95% (SDS-PAGE). The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as ``readers'' of histone acetylation marks regulating the transcription of target promoters. p300/CBP-associated factor (PCAF) is a transcriptional coactivator that works both as a histone lysine acetyltransferase, through its HAT domain, and as an acetyl-lysine reader through its conserved bromodomain located directly C-terminal to the HAT domain. The PCAF bromodomain binds acetylated histone H3 and H4 as well as non-histone targets. Bromodomain binding is dictated by the position |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PCAF, Recombinant, Mouse, His-Tag (Histone Acetyltransferase PCAF, Histone Acetyltransferase KAT2B, Lysine Acetyltransferase 2B, P/CAF, P300/CBP-Associated Factor) |
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| Gene, Accession, CAS # | Kat2b, Gene ID: 18519, SwissProt: Q9JHD1 |
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| Catalog # | 301262 |
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| Order / More Info | PCAF, Recombinant, Mouse, His-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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