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| Product Name | FBXW7, Recombinant, Human, aa1-707, His-Tag (F-box/WD Repeat-containing Protein 7) |
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| Description | Purity ~90% (SDS-PAGE). Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). Source: Recombinant protein corresponding to aa1-707 from human FBXW7, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~83.7kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Archipelago homolog1, hAgo1 F-box and WD-40 domain-containing protein 7, F-box protein, FBX301 SEL-101 hCdc4 |
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| Gene, Accession, CAS # | SwissProt: Q969H0 |
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| Catalog # | 373294 |
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| Order / More Info | FBXW7, Recombinant, Human, aa1-707, His-Tag (F-box/WD Repeat-containing Protein 7) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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