| 产品详情 |
| Edit |   |
|---|
| Product Name | Cdk4 Inhibitor V |
|---|
| Description | Purity ~98% (HPLC). A cell-permeable pyridinylmethylamino-isoquinoline dione compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of Cdk4/D1 activity with selectivity over Cdk2/E and Cdk1/B (IC50=0.03, 1.6 and 25.3uM, respectively). Shown to block the phosphorylation of Rb and induce growth arrest in HCT116 and MCF-7 cells (IC50=0.73 and 0.88uM). Displays desirable metabolic stability in rat liver microsomes and in the presence of NADPH and UDPGA cofactors (t1/2 > 30mins). Formula: C19H18IN3O4: Solubility: DMSO Molecular Weight: 479.3 |
|---|
| Size | 5mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Cdk4 Inhibitor V (4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217265 |
|---|
| Price | |
|---|
| Order / More Info | Cdk4 Inhibitor V from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|