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| Product Name | Pancreatitis-Associated Protein 1, Recombinant, Human |
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| Description | Purity ≥95% (SDS-PAGE);. Pancreatitis-associated protein (PAP) is a secretory protein not normally expressed in healthy pancreas but highly induced during acute pancreatitis. While PAP has been shown to be anti-bacterial and antiapoptotic in vitro, its definitive biological function in vivo is not clear. Using antisepse oligonucleotides, inhibition of PAP expression significantly worsened pancreatitis in a rat model. During pancreatitis, PAP released by the pancreas could mediate lung inflammation through induction of hepatic TNFalpha expression and subsequent increase in circulating TNFalpha. PAP is activated in primary liver cancers. In normal liver, the protein is undetectable in normal mature hepatocytes and found only in some ductular cells, representing potential hepatic progenitor cells. PAP can be considered hepatic cytokine that combines mitogenic and anti-apoptotic functions regarding hepatocytes, and consequently acts as a growth factor in vivo to enhance liver regeneration. |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Pancreatitis-Associated Protein 1, Recombinant, Human (PAP1, Regenerating Protein 3, REG3, REG-III) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P3000-60 |
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| Order / More Info | Pancreatitis-Associated Protein 1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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