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| Product Name | Thioredoxin Reductase 2, SelCys523Cys, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence(-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55 - 58kD in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR pla |
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| Size | 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Thioredoxin Reductase 2, SelCys523Cys, Recombinant, Human (Thioredoxin Reductase 2, Mitochondrial, Selenoprotein Z, SelZ, TR-beta, Thioredoxin Reductase TR3, TXNRD2, KIAA1652, TRXR2) |
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| Gene, Accession, CAS # | SwissProt: Q99757 |
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| Catalog # | T5010-16M |
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| Order / More Info | Thioredoxin Reductase 2, SelCys523Cys, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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