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| Product Name | UBE2S, Recombinant, Human, aa1-222, GST-Tag (Ubiquitin-conjugating Enzyme E2 S) |
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| Description | Purity ~90% (SDS-PAGE). Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. Source: Recombinant protein corresponding to aa1-222 from human UB |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | E2 ubiquitin-conjugating enzyme S, E2-EPF Ubiquitin carrier protein S, Ubiquitin-conjugating enzyme E2-24kD |
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| Gene, Accession, CAS # | SwissProt: Q16763 |
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| Catalog # | 375752 |
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| Order / More Info | UBE2S, Recombinant, Human, aa1-222, GST-Tag (Ubiquitin-conjugating Enzyme E2 S) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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