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| Product Name | U731221-(6-(17β-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione |
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| Description | Purity ~98% (TLC). U73122 inhibits agonist induced phospholipase C (PLC) activation in human platelets and neutrophils. This compound also inhibits agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. U73122 is a useful tool for investigating receptor-mediated PI turnover in signal transduction and is a potent inhibitor of human neutrophil adhesion to biological surfaces, as well as adhesion-dependent granule exocytosis and oxidative burst. Biological Activity: IC50 = 1.0-2.1uM (agonist induced PLC activation in human platelets and neutrophils) Solubility: Soluble in chloroform; soluble in methylene chloride; soluble in DMSO at a concentration of 2mg/ml; and soluble in ethanol at a concentration of 1mg/ml. Suggested Reconstitution: Because U73122 is only slightly soluble in aqueous media, it is best delivered to cells either when dissolved in organic solvents or when complexed with serum proteins. The following methods of reconstitution and delivery t |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(6-(17β-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | U0550 |
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| Order / More Info | U731221-(6-(17β-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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