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| Product Name | Hepatitis C Virus E2, Recombinant, aa482-671, His-Tag (HCV) |
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| Description | Purity ~80% (SDS-PAGE). E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. Source: Recombinant protein corresponding to aa482-671 from HCV (Hepatitis C Virus) E2, fused to His-tag at N-terminus, expressed |
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| Size | 100ug, 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_671491 |
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| Catalog # | 218216 |
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| Order / More Info | Hepatitis C Virus E2, Recombinant, aa482-671, His-Tag (HCV) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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