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| Product Name | Defensins, alpha, Human, Neutrophils |
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| Description | Purity ~95% (SDS-PAGE). Background Information: Alpha defensins are a family of mammalian defensin peptides. In general, defensins are small cysteine-rich cationic proteins found in both vertebrates and invertebrates. These mixed alpha defensins are purified from human neutrophils. These peptides are active in killing bacteria, fungi, and enveloped viruses, and therefore, enable the neutrophils to inactivate and destroy potential pathogens. Defensins damage or kill ingested microbes by penetrating the microbial' s cell membrane by way of electrical attraction, and consequently forming pores in the membrane. Human neutrophil-derived alpha-defensins (HNPs) are capable of enhancing phagocytosis by mouse macrophages. HNP1-3 have been reported to increase the production of tumor necrosis factor (TNF) and IL-1, while decreasing the production of IL-10 by monocytes. Increased levels of proinflammatory factors (e.g., IL-1, TNF, histamine and prostaglandin D2) and suppressed levels of IL-10 at |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Defensins, alpha, Human, Neutrophils (HNP, Human Neutrophil Peptides, Neutrophil defensin 4, Defensin, alpha 4, HNP-4) |
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| Gene, Accession, CAS # | HNP-4, Gene ID: 1669, SwissProt: P12838 |
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| Catalog # | D6025 |
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| Order / More Info | Defensins, alpha, Human, Neutrophils from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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