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| Product Name | FZR1, Recombinant, Human, aa1-493, His-SUMO-Tag (Fizzy-related Protein Homolog) |
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| Description | Purity ~90% (SDS-PAGE). Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacent of CDC20, and activates the APC/C during anaphase and telophase. The APC/C rains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate praturely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Source: Recombinant protein corresponding to aa1-493 from human FZR1, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~70.8kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CDC20-like protein 1, Cdh1/Hct1 homolog, hCDH1 |
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| Gene, Accession, CAS # | SwissProt: Q9UM11 |
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| Catalog # | 373378 |
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| Order / More Info | FZR1, Recombinant, Human, aa1-493, His-SUMO-Tag (Fizzy-related Protein Homolog) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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