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| Product Name | LOXL2, Recombinant, Human |
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| Description | Purity ~90% (SDS-PAGE, reducing conditions). Lysyl Oxidase Homolog 2 (lysyl oxidase-like protein 2, LOXL2) is a member of lysyl oxidase-like (LOXL) gene family which includes LOXL1 through LOXL4. These enzymes are secreted copper-binding amine oxidases that oxidize primary amine substrates to aldehydes. The N-terminal region of LOXL2 contains four scavenger receptor cysteine- rich (SRCR) domains, and the C-terminal region is a catalytic domain similar to other lysyl oxidases. The catalytic domain contains conserved residues required for copper binding and formation of a lysyl tyrosylquinone co-factor. Although some of the LOXL enzymes are known to cross-link collagen and elastin substrates, such a function has yet to be characterized for LOXL2. It has been shown that LOXL2 promotes cell migration and tumor cell invasiveness. Elevated expression of LOXL2 is also associated with cancer progression in various tumors and carcinoma cell lines, which makes it a potential marker for prognosis |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LOXL2, Recombinant, Human (Lysyl Oxidase-like Protein 2, Lysyl Oxidase Related Protein 2, LOR2, Lysyl Oxidase Homolog 2, Lysyl Oxidase Related Protein WS9-14) |
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| Gene, Accession, CAS # | Accession: AAH00594 |
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| Catalog # | L2623-15A |
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| Order / More Info | LOXL2, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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