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| Product Name | Loxl2, Recombinant, Mouse, aa26-766, His-Tag (Lysyl Oxidase Homolog 2) |
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| Description | Purity ~90% (SDS-PAGE). Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in Extracellular domain matrix, promotes cross-linking of Extracellular domain matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (T) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. Source: Recombinant protein correspo |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Lysyl oxidase-like protein 2 |
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| Gene, Accession, CAS # | SwissProt: P58022 |
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| Catalog # | 374070 |
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| Order / More Info | Loxl2, Recombinant, Mouse, aa26-766, His-Tag (Lysyl Oxidase Homolog 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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