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| Product Name | Chk1 Substrate Peptide (Chktide) (CHEK1, Cell Cycle Checkpoint Kinase) (Biotin) |
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| Description | Highly Purified (Determined by HPLC and mass spectroscopy). Synthetic peptide([KKKVSRSGLYRSPSMPENLNRPR) (linear) biotinylated at the N-terminus. Substrate for CHK enzymes (C4200-10A). Chk1, one of the downstream protein kinases of ATM/ATR, plays an important role in DNA damage checkpoint, embryonic development and tumor suppression. The activation of Chk1 in response to replication blocks and certain forms of genotoxic stress involves phosphorylation of serines 317 and 345. Activated Chk1 can inactivate cdc25c via phosphorylation at serine 216, blocking the activation of cdc2 and transition into M-phase. Chk1 can also phosphorylate p53 at serine 20 in vitro. Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both function as essential components in the G2-DNA damage checkpoint by phosphorylating CDC25C in respons |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C4200-15A |
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| Order / More Info | Chk1 Substrate Peptide (Chktide) (CHEK1, Cell Cycle Checkpoint Kinase) (Biotin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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