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| Product Name | Heme Oxygenase 1, Recombinant, Human (HO-1, HSP32, Heat Shock Protein 32) |
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| Description | Purity ≥ 90% as determined by SDS-PAGE analysis. Heme oxygenase-1 (HO-1) or HSP32 is the inducible isoform of heme oxygenase which catalyzes the NADPH, O2 and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, iron and biliverdin that is immediately reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator; biliverdin and its product bilirubin are potent antioxidants; ``free' iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferrin receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'-or 3'-UTRs of the mRNAs. To date, three heme oxygenase isoforms HO-1, HO-2 and HO-3 have been identified. HO-1 or Hsp32, a major heat shock/stress response protein is ubiquitous and its mRNA as well as its activity can be increased several-fold by heme, other metalloporphy |
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| Size | 50ug, 200ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P09601 |
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| Catalog # | H1847-66 |
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| Order / More Info | Heme Oxygenase 1, Recombinant, Human (HO-1, HSP32, Heat Shock Protein 32) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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