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| Product Name | SAPKK3, active, Recombinant, Human |
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| Description | Purified using amylose resin beads and activated with MEK Kinase. MEK Kinase was removed using Ni-NTA chromatography. Mr ~81kD; purity ≥ 80% as determined by SDS-PAGE and coomassie blue staining. Mitogen-activated protein (MAP) kinases are activated by dual phosphorylation on threonine and tyrosine residues. The activation is carried out by the family of enzymes known as MAP Kinase Kinases (SKKs, MKKs or MEKs). There are at least four distinct SKKs/MKKs/MEKs identified in mammalian cell types: MKK1/MKK2 that activates Erk1/Erk2; MKK3 that activates Mpk2/p38 MAPK; MKK4 that activates p38 and Jun kinase; and MKK5 that activates ErkK5/BMK1. A newly described SKK/MKK has been termed SKK3/MKK6 or MEK6. SKK3/MKK6 is closely related to MKK3 and selectively phosphorylates p38. However, unlike the previously described SKKs/MKKs/MEKs, SKK3/MKK6 exists in a variety of alternatively spliced isoforms and unlike MKK4 is not regulated by rac or Cdc42. Specific Activity: 33u/mg using myelin basic prot |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SAPKK3, active, Recombinant, Human (Stress-activated Protein Kinase Kinase 3, SAPK Kinase 3, SAPKK-3, SKK3, Dual Specificity Mitogen-Activated Protein Kinase Kinase 6, MAP Kinase Kinase 6, MAP2K6, MAPKK 6, MAPKK6, MKK6, PRKMK6, MAPK/ERK Kinase 6, MEK 6, MEK6) |
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| Gene, Accession, CAS # | Accession: NM_002758.3, SwissProt: P52564 |
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| Catalog # | S0096-02A |
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| Order / More Info | SAPKK3, active, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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