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| Product Name | SAPK2, p38 MAPK Inhibitor (SB 202190) (Stress-activated Protein Kinase 2) |
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| Description | Purity ~98% (HPLC). SB 202190 is a cell permeable pyridinyl imidazole, which acts as a strong inhibitor of SAPK2a/p38 and SAPK2b/p38beta MAP kinases (IC50=280nM and 350nM, respectively). SB 202190 has no effect on the activity of the Erk or SAPK/JNK MAP kinases and is reported to block LPS induced TNF-a and IL-1beta production in mice. The compound is a slightly better inhibitor than the related compound SB 203580. Solubility: Soluble in DMSO (50mg/ml). Applications: Specific inhibitor of p38/SAPK2a MAPK and P38b/SAPK2a MAPK activity. Protein Kinase Inhibition Assay: When pre-incubated for five minutes with 0.2ug of SAPK2a/p38 MAPK or SAPK2b/p38beta MAPK, 1-10uM of SB 202190 will inhibit the activity of these kinases 80-95%. The final concentration of SB 202190 needed may depend on the amount of enzyme used. Optimal dilutions to be determined by the researcher. |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q15759 |
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| Catalog # | S0096-25 |
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| Order / More Info | SAPK2, p38 MAPK Inhibitor (SB 202190) (Stress-activated Protein Kinase 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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