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| Product Name | Midkine, Recombinant, Mouse (MK, NEGF-2) |
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| Description | Purity ~98% (SDS-PAGE). Midkine and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorigenesis. Source: Recombinant protein corresponding to 120aa residues, including five intra-molecular disulfide bonds, from mouse Midkine, expressed in E. coli. Molecular Weight: ~13.3kD Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100ng/ml. Endotoxin: <0.1ng/ug of protein (<1EU/ug) AA Sequence: VAKKKEKVKK GSECSEWTWG PCTPSSKDCG MGFREGTCGA QTQRVHCKVP CNWKKEFGAD CKYKFESWGA CDGSTGTKAR QGTLKKARYN AQCQETIRVT KPCTSKTKS |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MK, NEGF-2 |
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| Gene, Accession, CAS # | MDK, Gene ID: 17242, SwissProt: P12025 |
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| Catalog # | 220045 |
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| Order / More Info | Midkine, Recombinant, Mouse (MK, NEGF-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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