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| Product Name | TIMP1, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE and HPLC). TIMP1 is an extracellular inhibitor of MMPs (see above) including MMP1, 2, 3, 7, 8, 9, 10, 11, 12, 13, and 16. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP1 can also act through an MMP-independent mechanism to promote erythropoiesis by stimulating proliferation and differentiation of erythroid progenitors. Recombinant human TIMP-1 is a 20.6kD protein containing 184aa. Source: Recombinant protein corresponding to human TIMP-1, expressed in E. coli. Biological Activity: TIMP1 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-1 concentration of approximately 0.5ug/ml, when using an MMP-1 concentration of 1.6ug/ml. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: CTCVPPHPQT AFCNSDLVIR AKFVGTPEV |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TIMP1, Recombinant, Human (Metalloproteinase Inhibitor 1, Erythroid-potentiating Activity, EPA, Fibroblast Collagenase Inhibitor, Collagenase Inhibitor Tissue Inhibitor of Metalloproteinases 1, TIMP-1, CLGI, TIMP) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149568 |
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| Order / More Info | TIMP1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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