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| Product Name | TIMP2, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE and HPLC). TIMP-2 is an extracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13, 14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP-2 can also act through an MMP-independent mechanism inhibiting endothelial cell proliferation in vitro and demonstrates anti-angiogenic activities in vivo. Recombinant human TIMP-2 is a 21.8kD protein containing 194aa. Source: Recombinant protein corresponding to human TIMP-2, expressed in E. coli. Biological Activity: TIMP-2 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-2 concentration of approximately 0.5ug/ml, when using an MMP-1 concentration of 1.6ug/ml. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: MCSCSPVHPQ QAFCNADVVI RAKAVSEK |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TIMP2, Recombinant, Human (Tissue Inhibitor of Metalloproteinases 2, TIMP-2, Metalloproteinase Inhibitor 2, CSC-21K, DDC8) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149569 |
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| Order / More Info | TIMP2, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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