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| Product Name | IL10 BioAssay™ ELISA Kit (Rat) (Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, IL10) |
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| Description | Interleukin 10 (IL-10), originally known as cytokine synthesis inhibitory factor (CSIF), is a pleiotropic cytokine with a myriad of immunomodulatory effects on a variety of cell types. On activated B cells, IL-10 can induce the formation of plasma cells and the secretion of IgG or, in the presence of TGF-beta1 and/or IL-4, the secretion of IgA. On macrophages, IL-10 is known to downregulate IL-1, TNF-alpha and IL-6 production. On dendritic cells, IL-10 has been shown to interfere with antigen-presenting cell (APC) functions by downmodulating the expression of stimulatory and co-stimulatory molecules. IL-10 has also been found to inhibit dendritic cell differentiation from monocytes and to promote monocyte maturation into cytotoxic CD16+ macrophages. Rat IL-10 cDNA encodes a 178 aa residue precursor protein that contains an 18aa signal sequence and a 160aa mature protein. Mature rat IL-10 shares 85% and 74%aa sequence identity with mouse and human IL-10, respectively. Sample Type: Cell |
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| Size | 48 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 360533 |
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| Order / More Info | IL10 BioAssay™ ELISA Kit (Rat) (Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, IL10) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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