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| Product Name | IL-23, Recombinant, Human (Interleukin-23) |
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| Description | Purity >90% (SDS-PAGE). Interleukin-23 (IL-23) is a heterodimeric cytokine and a member of the IL-12 family involved in innate and adaptive immunity. It is composed of the IL-12 p40 chain covalently linked to p19, a chain related to the IL-12 p35 subunit. IL-23 signals through the IL-23 receptor complex, which is composed of the IL-12Rbeta1 chain and a gp130-like chain, IL-23R. Triggering of the IL-23 receptor complex leads to the activation of Tyk2, Jak2 and STAT1, 3 and 4. IL-23 induces IFN-gamma production, Th1 cell differentiation, and activation of the antigen-presenting functions of dendritic cells. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and important for tumorigenesis. Biological Activity: Induction of IL-17 secretion by mouse splenocytes. Sequence: Human IL-23 p40 peptide (aa 23-328) is fused at the C-terminus to a 18 aa linker peptide (GSTSGSGKPGSGEGSTKG) and to the p19 peptide (aa 20-189) and fused at the N-termi |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Interleukin-23 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 44912 |
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| Order / More Info | IL-23, Recombinant, Human (Interleukin-23) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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