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| Product Name | IL-17, Recombinant, Human (Interleukin-17, IL-17A, Interleukin-17A) |
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| Description | Purity ~98% (RP-HPLC, SDS-PAGE). IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. It is also suspected to play a role in Autism. Source: Recombinant protein corresponding to human IL-17, a homodimeric, non-glycosylated polypeptide chain containing a total of 264aa, expressed in E. coli. Molecular Weight: ~30.25kD Biological Activity: The ED50, as determined by the dose-dependant induction of IL-6 in primary human foreskin fibroblasts, was found to be 2ng/ml, corresponding to a specific activity of 5x10e5 Units/mg. AA Sequence: The sequence of the first five N-terminal amino acids was determined and was fo |
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| Size | 5ug, 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 299422 |
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| Order / More Info | IL-17, Recombinant, Human (Interleukin-17, IL-17A, Interleukin-17A) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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