| 产品详情 |
| Edit |   |
|---|
| Product Name | Prothrombin BioAssay™ ELISA Kit (Antibodies only) |
|---|
| Description | Prothrombin (factor II, F.II) is a vitamin K-dependent glycoprotein produced in the liver. The concentration of prothrombin in plasma is ~100ug/ml (~1.4uM). Prothrombin is a single chain molecule with a molecular weight of 72kD. Prothrombin consists of a catalytic domain followed by two kringle structures and an aminoterminal domain containing 10 gamma-carboxy-glutamic acid (gla) residues. These gla residues allow prothrombin to bind to membranes that contain acidic phospholipids in a calcium dependent manner. The binding to membranes is required for effective presentation of prothrombin as a substrate for activation by the prothrombinase complex, which consists of activated factor X, activated cofactor V and calcium on phospholipid membrane. Activation by prothrombinase occurs by sequential cleavage after residue Arg320 then after Arg271 to produce the active protease a- thrombin (37kD) and the by-product prothrombin fragment 1.2 (35kD). The product thrombin further cleaves prothrombi |
|---|
| Size | 1 kit |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | P9117 |
|---|
| Price | |
|---|
| Order / More Info | Prothrombin BioAssay™ ELISA Kit (Antibodies only) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|