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| Product Name | NTB-A, Fc Chimera, Recombinant, Human (SLAMF6) |
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| Description | Purity ≥ 90%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin ≤ 1EU. NTB-A (NK-T-B-antigen), also known as Ly108 and SLAMF6, is a 60kD type I transmembrane glycoprotein that belongs to the SLAM subgroup of the CD2 family (1). Mature human NTB-A contains a 205 amino acid (aa) extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain. It also contains a 21 aa transmembrane segment and an 84 aa cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs (ITSMs) (2, 3). An alternately spliced isoform is truncated in the cytoplasmic domain and lacks the two ITSMs. Within the ECD, human NTB-A shares 48% aa sequence identity with mouse and rat NTB-A. The ECD of human NTB-A shares 19%-34% aa sequence identity with comparable regions of human 2B4, BLAME, CD2F-10, CD84, CD229, CRACC, and SLAM. NTB-A is expressed on the surface of NK, T, and B lymphocytes as well as eosinophils (2, 4, 5). It interacts homophilically through weak associations b |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q96DU3 |
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| Catalog # | N6000-35H |
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| Order / More Info | NTB-A, Fc Chimera, Recombinant, Human (SLAMF6) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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