| 产品详情 |
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| Product Name | SOD1 Inhibitor, LCS-1 |
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| Description | Purity ~99% (HPLC). A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50=1.07uM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50=200nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6min in human liver microsomes. Formula: C11H8Cl2N2O Solubility: DMSO (50mg/ml, clear, colorless solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SOD1 Inhibitor, LCS-1 (4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, Superoxide Dismutase 1 Inhibitor, Lung Cancer Screen 1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217802 |
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| Order / More Info | SOD1 Inhibitor, LCS-1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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