| 产品详情 |
| Edit |   |
|---|
| Product Name | TNFRSF21, Recombinant, Human, aa371-655, His-SUMO-Tag (Tumor Necrosis Factor Receptor Superfamily Member 21) |
|---|
| Description | Purity ~90% (SDS-PAGE). Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and |
|---|
| Size | 10ug, 50ug, 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | SwissProt: O75509 |
|---|
| Catalog # | 375624 |
|---|
| Price | |
|---|
| Order / More Info | TNFRSF21, Recombinant, Human, aa371-655, His-SUMO-Tag (Tumor Necrosis Factor Receptor Superfamily Member 21) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|