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| Product Name | Lck, p56lck, active, Recombinant, Human (Lymphocyte-specific Tyrosine Kinase) |
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| Description | Purity ≥ 90% by densitometry. LCK (p56lck) is a member of the Src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and over-expressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene (1). LCK behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show over-expression of LCK, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers (2). Source: Recombinant full-length human LCK was expressed by baculovirus in Sf 9 insect cells using an N-terminal GST tag. The gene accession number is NM_005356. Molecular Mass: The approximate molecular weight is 84 kD. Activity: The specific activity of LCK was determined to be 239 nmol/min/mg using a Poly (Glu:Tyr, 4:1) synthetic peptide substrate (see activity assay protocol). |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_005356 |
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| Catalog # | L1565-06C |
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| Order / More Info | Lck, p56lck, active, Recombinant, Human (Lymphocyte-specific Tyrosine Kinase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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