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| Product Name | Lck, Recombinant, Human, aa1-539, His-SUMO-Tag (Tyrosine-Protein Kinase LCK) |
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| Description | Purity ~90% (SDS-PAGE). Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the Cytoplasmic domain portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the Cytoplasmic domain tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules a |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Leukocyte C-terminal Src kinase, LSK Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16 Proto-oncogene LckT cell-specific protein-tyrosine kinase, p56-LCK |
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| Gene, Accession, CAS # | SwissProt: P06239 |
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| Catalog # | 373992 |
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| Order / More Info | Lck, Recombinant, Human, aa1-539, His-SUMO-Tag (Tyrosine-Protein Kinase LCK) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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