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| Product Name | Lipopolysaccharide Binding Protein, aa26-481, Recombinant, Human, His-Tag (LBP, LPSBP) |
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| Description | Purity ~95% (SDS-PAGE). LBP (Lipopolysaccharide binding protein) is a 58-62kD, glycoprotein member of the BPI/LBP family of lipid-binding proteins (1-4). It is secreted by hepatocytes, gingival keratinocytes, intestinal paneth cells, type II Greater alveolar cells, lacrimal and submandibular gland epithelium, and caudal epididymal epithelium (5-10). LBP is a class 1 APR (acute phase reactant) that is induced upon exposure to both IL-1 and IL-6 (11). Following its synthesis and release, LBP interacts with bacterial wall components, lipopolysaccharide/LPS/Lipid A from Gram- (Gm-) bacteria, and lipoteichoic acid/LTA from Gm+ bacteria (12-16). In the case of LPS, this interaction occurs both in the bacterial cell wall, and within the intercellular space, where LPS micelles naturally form following bacterial death and cell wall dissolution (17-20). LBP induces disassembly of LPS micelles, allowing for LPS binding to LBP, and a heparin-mediated transfer of LPS from LBP to membrane-bound CD14 |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: CAA67226 |
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| Catalog # | L2525-30A |
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| Order / More Info | Lipopolysaccharide Binding Protein, aa26-481, Recombinant, Human, His-Tag (LBP, LPSBP) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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