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| Product Name | 4-1BB Ligand, Recombinant, Human (TNFSF9, CD137L) |
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| Description | Purity ≥98% by SDS-PAGE gel and HPLC analyses. 4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages.4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion.The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain.The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL.Recombinant human 4-1BBL is a soluble 19.5kD protein consisting of 185 amino acid residues. Biological Activity: Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10ng/ml. Note: Results may vary with PBMC donors. AA Sequence: MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLH |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143267 |
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| Order / More Info | 4-1BB Ligand, Recombinant, Human (TNFSF9, CD137L) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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