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| Product Name | SETD7, Recombinant, Human, aa110-366, His-SUMO-Tag, Myc-Tag (Histone-lysine N-methyltransferase SETD7) |
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| Description | Purity ~85% (SDS-PAGE). Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Source: Recombinant protein corresponding to aa110-366 from human Histone-lysine N-methyltransferase SETD7, fused to His-SUMO-Tag at N-terminal and fused to Myc-Tag at C-terminal, expressed in E. coli. Molecular Weight: ~48.7kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q8WTS6 |
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| Catalog # | 406039 |
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| Order / More Info | SETD7, Recombinant, Human, aa110-366, His-SUMO-Tag, Myc-Tag (Histone-lysine N-methyltransferase SETD7) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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