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| Product Name | Noggin, Recombinant, Human |
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| Description | Purity ≥ 95% by SDS-PAGE gel and HPLC analyse. Endotoxin: ≤ 0.1ng/ug (1EU/ug). Noggin belongs to a group of structurally diverse diffusible proteins which bind TGF-beta ligands and inhibit their access to membrane receptors. This natural antagonist displays high binding-affinity for BMP-2 and -4 and a lower affinity for BMP-7 (OP-1). This protein is secreted as a disulfide-linked homodimer, however the non-disulfide-linked also assume dimeric structure and displays similar biological activity. Recombinant human Noggin is a 23.1kD non-disulfide-linked homodimer consisting of 206 amino acid residues. Biological Activity: The ED50 was determined by its ability to inhibit 5ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.05-0.08ug/ml of NOGGIN. AA Sequence: MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYV |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | N3100 |
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| Order / More Info | Noggin, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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