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| Product Name | Akt1, active, Recombinant, Human |
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| Description | Purity ~90% (SDS-PAGE). Akt1 or Protein Kinase B alpha (PKBa) is a serine/threonine kinase that belongs to the Akt family. Akt1 is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility (1). The PI3K generates phosphatidylinositol-3,4,5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of Akt1 to the plasma membrane where it is phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1) (2) and phosphoinositide-dependent kinase-2 (possibly ILK) (3). Akt1 has numerous cellular substrates including proteins, which promote the inhibition of apoptosis such as the Forkhead transcription factors and the Bcl-2 family member Bad (4). In addition, the cyclin dependent kinase inhibitors are substrates of Akt which when phosphorylated relinquish their inhibitory influence on |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Akt1, active, Recombinant, Human (RAC-alpha Serine/Threonine-protein Kinase, Protein Kinase B, PKB, Protein Kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC, RAC-PK-alpha) |
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| Gene, Accession, CAS # | Accession: NM_005163, SwissProt: P31749 |
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| Catalog # | A1125-06K |
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| Order / More Info | Akt1, active, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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