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| Product Name | Prouroguanylin, Recombinant, Human |
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| Description | Purity ~95% (RP-HPLC, SDS-PAGE). Prouroguanylin is a 112aa prohormone precursor of uroguanylin-mature biologically active 16aa peptide cleaved from its C-terminus. Guanylin binds to receptor-guanylate cyclases (CG-C) resulting in increased intracellular cGMP levels leading to CFTCR (Cystic Fibrosis Transmembrane Conductance Regulator) activation and subsequent rise in fluid and electrolyte secretion into the lumen. Prouroguanyline knock-out mice showed impaired renal excretion of external NaCl leading to elevated blood pressure independent of the level of diatary salt intake. Prouroguanylin is the predominant circulating molecular form found in circulation and in biological fluids. Source: Recombinant protein corresponding to 88aa and 2 additional aa from human Prouroguanylin, expressed in E. coli. Molecular Weight: ~10kD Specificity: The recombinant sequence is 100% homologous to the native human sequence. Applications: Suitable for use in ELISA and Western Blot. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209163 |
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| Order / More Info | Prouroguanylin, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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