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| Product Name | Prouroguanylin, Recombinant, Human |
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| Description | Purity ≥ 95% (SDS-PAGE and HPLC analyzed); Three-step procedure using IMAC and size exclusion chromatography before and after refolding. Prouroguanylin is a 112-amino-acid prohormone precursor of uroguanylin- mature biologically active 16-amino-acid peptide cleaved from its C-terminus. Guanylin binds to receptor-guanylate cyclases (CG-C) resulting in increased intracellular cGMP levels leading to CFTCR (Cystic Fibrosis Transmembrane Conductance Regulator) activation and subsequent rise in fluid and electrolyte secretion into the lumen. Prouroguanyline knock-out mice showed impaired renal excretion of external NaCl leasing to elevated blood pressure independent of the level of diatary salt intake. Prouroguanylin is the predominant circulating molecular form found in circulation and in biological fluids. Description: The Recombinant Human Prouroguanylin is 10kD protein containing 88 amino acid residues of the human prouroguanylin and 2 additional amino acid residues. Amino Acid Sequence: |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P9119-90 |
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| Price | |
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| Order / More Info | Prouroguanylin, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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