| 产品详情 |
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| Product Name | CARM1 Inhibitor |
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| Description | Purity ~95% (HPLC). A cell-permeable (bis-benzylidene)piperidinone compound that acts as a selective inhibitor against CARM1/PRMT4 arginine methyltransferase activity (IC50=7.1uM with PABP1 as substrate). It inhibits PRMT3 only at much higher concentrations (by 70% and 62% with 100uM inhibitor using NPL3 or rpS2 as substrate, respectively), exhibiting little activity against PRMT1, PRMT5, PRMT6 (IC50>100uM), or four HKMTs (<20% inhibition against DOTL1, G9a, SET7, or Suv39H1 with 100uM inhibitor). Shown to inhibit PSA promoter-mediated reporter transcription in LNCaP cells in a dose-dependent manner (by 74% and 97%, respectively, with 4 and 6uM inhibitor). Formula: C26H21Br2NO3 Primary Target: PRMT4 Primary Target IC50: CARM1-mediated methylation over PRMT1 and SET7 (IC50 = 7.1, 63 and 943uM Secondary target: SET7 Molecular Weight: 555.3 Solubility: DMSO |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CARM1 Inhibitor (1-Benzyl-3,5-bis-(3-bromo-4-hydroxybenzylidene)piperidin-4-one, 3,5-bis(3-Bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one, Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, PRMT Inhibitor V) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217249 |
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| Price | |
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| Order / More Info | CARM1 Inhibitor from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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