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| Product Name | Glucokinase Regulatory Protein, Control Peptide (GCKR, GKRP) |
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| Description | Control peptide for G2023-37. Hexokinase catalyzes the first step of several metabolic pathways by converting D-hexose to D-hexose-6-P. Hexokinase is an allosteric enzyme inhibited by its products glucose-6-phosphate. At least 4 related hexokinase isoforms (HXKI-III; HXK-IV also known as Glucokinase) have been cloned and characterized. Hexokinases (~100kD for HXK1-III; HXKIV lacks the N-terminal domains and is ~50kD) are outer mitochondrial membrane proteins. The N- terminus, containing the mitochondrial target sequence, and the C- terminal has high sequence homology among various isoforms. The catalytic activity is associated with the C-terminus and other regulatory functions are controlled by the N-terminus. Glucokinase (GCK) in the liver and pancreatic beta cells is subject to inhibition by a regulatory protein, GCKR or GKRP. The inhibitory effect of GCKR depends on the presence of fructose-6-phosphate and is antagonized by fructose-1-phosphate. Mutations in GCKR might be diabetogen |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | G2023-37A |
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| Order / More Info | Glucokinase Regulatory Protein, Control Peptide (GCKR, GKRP) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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