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TAK1-TAB1, Fusion Protein, Recombinant, Human, GST-Tag (TAK1: MAP3K7, TGF1a, TAB1: MAP3K7IP1, 3'-Tab1) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | TAK1-TAB1, Fusion Protein, Recombinant, Human, GST-Tag (TAK1: MAP3K7, TGF1a, TAB1: MAP3K7IP1, 3'-Tab1) |
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| Description | Purified (~70-90%). TAK1 is a serine/threonine protein kinase that mediates signaling by TGFbeta and morphogenetic protein (BMP). In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (NfB). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8. Thymocytes lacking TAK1 fail to activate NfB and JNK and are prone to apoptosis upon stimulation. Source: Recombinant protein corresponding to human TAK1-TAB1, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~74kD Specific Activity: 10nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_003188, NM_006116, SwissProt: O43318 |
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| Catalog # | 500476 |
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| Order / More Info | TAK1-TAB1, Fusion Protein, Recombinant, Human, GST-Tag (TAK1: MAP3K7, TGF1a, TAB1: MAP3K7IP1, 3'-Tab1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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