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| Product Name | Hydroxysteroid Dehydrogenase, 11-beta Type II, Human (11b-HSD2) (Control Peptide) |
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| Description | Highly purified. Control Peptide for H9117-50G (antiserum) and H9117-50H (affinity purified) antibodies. 11-b-hydroxysteroid dehydrogenase (11b-HSD) is a microsomal short chain dehydrogenase/reductase (SDR) which catalyzes the inter-conversion of biologically active glucocorticoid (cortisol in human and corticosterone in rats and mice) and inactive glucocorticoid (cortisone and 11-dehydrocorticosterone). Two tissue specific isoforms (11b-HSD1 and 11b-HSD2) of 11b-HSD with two different functions regarding glucocorticoid availability, have been identified. The decreased 11b-hydroxy oxidation of cortisol results in Apparent Mineralocorticoid Excess (AME) disorder which is manifested by hypertension, hypokalemia, low plasma renin activity, and responsiveness to spironolactone. AME is principally a disorder of juveniles and children with this condition oxidize cortisol to cortisone poorly but carry out the reverse process unimpaired. AME arises from mutations in the 11b-HSD2 gene. The gluc |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H9117-50L |
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| Order / More Info | Hydroxysteroid Dehydrogenase, 11-beta Type II, Human (11b-HSD2) (Control Peptide) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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