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| Product Name | MGMT, Recombinant, Human (O6-Methylguanine DNA Methyltransferase) |
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| Description | Purified ≥ 95% by SDS-PAGE. O-6-methylguanine-DNA methyltransferase (MGMT) is an enzyme that repairs O-6-methylguanine, a mutagenic DNA base damaged by endogenous and environmental alkylating agents and is involved in the cellular defense against the biological effects of O-6-methylguanine in DNA. MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. There are few reports that abnormal MGMT expression correlates with the prognosis in human solid cancers. Recombinant MGMT, fused to His-tag at N-terminus, was expressed in E.coli and was purified by conventional chromatography techniques. Source: Recombinant corresponding to aa1-207 of human MGMT (His-tagged) expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM QCTAWLNAYF HQPEAIEEFP VPAFHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA |
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| Size | 100ug, 500ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_002403 |
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| Catalog # | M3884-91C |
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| Order / More Info | MGMT, Recombinant, Human (O6-Methylguanine DNA Methyltransferase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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