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| Product Name | FLT3, Recombinant, Human, GST-Tag (FMS-related Tyrosine Hinase 3, FLK2, STK1, CD135) |
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| Description | Purified (~70-90%). FLT3 is a receptor tyrosine kinase that has been shown to play a role in proliferation and survival of hematopoietic progenitor cells as well as differentiation of early B lymphoid progenitors. FLT3 consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30 to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3. The consequence of either FLT3-ITD or activating loop mutations is the constitutive activation of the tyrosine kinase activity. Source: Recombinant protein corresponding to human FLT3 fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~73kD Specific Activity: 81nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_004119 |
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| Catalog # | 500019 |
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| Order / More Info | FLT3, Recombinant, Human, GST-Tag (FMS-related Tyrosine Hinase 3, FLK2, STK1, CD135) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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