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| Product Name | Vpx, Recombinant, Human, aa1-112, His-SUMO-Tag (Immunodeficiency Virus Type 2 Subtype A Protein Vpx) |
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| Description | Purity ~90% (SDS-PAGE). Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity). Source: Recombinant protein corresponding to aa1-112 from human vpx, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~28.8kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Viral protein, X X ORF protein |
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| Gene, Accession, CAS # | SwissProt: P06939 |
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| Catalog # | 375845 |
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| Order / More Info | Vpx, Recombinant, Human, aa1-112, His-SUMO-Tag (Immunodeficiency Virus Type 2 Subtype A Protein Vpx) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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