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| Product Name | TLR4 Inhibitor, TAK-242 |
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| Description | Purity ~98% (HPLC). A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9nM, respectively, against LPS-induced NO, IL-6, and TNF-alpha production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7mg/kg, i.p.) induced death in mice (3mg/kg; i.v.) in vivo. Primary Target: TLR4 Solubility (100mg/ml): DMSO Carbon: As Reported Hydrogen: As Reported Nitrogen: As Reported Sulfur: As Reported |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TLR4 Inhibitor, TAK-242 (Ethyl-(6R)-6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217838 |
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| Order / More Info | TLR4 Inhibitor, TAK-242 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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