| 产品详情 |
| Edit |   |
|---|
| Product Name | STAT3 Inhibitor XIII, C188-9 |
|---|
| Description | Purity ~97% (HPLC). A cell-permeable binaphthol-sulfonamide compound that competitively disrupts Stat3 SH2 domain-pY peptide interaction and acts as a reversible inhibitor of Stat3 activation and Stat3-dependent gene transcription. Shown to block G-CSF stimulated pStat3 (IC50=4.1, 4.5 and 8.3uM in KG-1, Kasumi-1 and NB-4 cells, respectively), with no effect on ligand-induced pStat1 and selectively induce apoptosis of Stat3-dependent AML cells ((EC50 of 6-8uM) and growth arrest. Moderately affects Tie2 kinase activity (< 50%) with minimal effect on JAK1, JAK2, Src family kinases and pERK1/2 and pAKT at 10uM. Formula: C27H21NO5S Molecular Weight: 471.5 Solubility: DMSO (100mg/ml) ( |
|---|
| Size | 10mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | STAT3 Inhibitor XIII, C188-9 (N-(1',2-Dihydroxy-1,2'-binaphthalen-4'-yl)-4-methoxybenzenesulfonamide, F1113-0789) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217811 |
|---|
| Price | |
|---|
| Order / More Info | STAT3 Inhibitor XIII, C188-9 from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|