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| Product Name | STAT3 Inhibitor XVI (IL-6 Inhibitor) |
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| Description | Purity ~98% (HPLC). A cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50=15uM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30uM and 30-100uM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level. Formula: C21H22N2O3S3 Molecular Weight: 446.08 Solubility: DMSO (50mg/ml, light pink-purple solution) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217813 |
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| Order / More Info | STAT3 Inhibitor XVI (IL-6 Inhibitor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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